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|
疾病名 |
飲酒量(純アルコール量(g)) |
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|
男性 |
女性 |
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|
研究結果 (参考) |
研究結果 (参考) |
||
|
1 |
脳卒中(出血性) |
150g/週 (20g/日) |
0g＜ |
|
2 |
脳卒中(脳梗塞) |
300g/週 (40g/日) |
75g/週 (11g/日) |
|
3 |
虚血性心疾患・心筋梗塞 |
※ |
※ |
|
4 |
高血圧 |
0g＜ |
0g＜ |
|
5 |
胃がん |
0g＜ |
150g/週 (20g/日) |
|
6 |
肺がん(喫煙者) |
300g/週 (40g/日) |
データなし |
|
7 |
肺がん(非喫煙者) |
関連なし |
データなし |
|
8 |
大腸がん |
150g/週 (20g/日) |
150g/週 (20g/日) |
|
9 |
食道がん |
0g＜ |
データなし |
|
10 |
肝がん |
450g/週 (60g/日) |
150g/週 (20g/日) |
|
11 |
前立腺がん(進行がん) |
150g/週 (20g/日) |
データなし |
|
12 |
乳がん |
データなし |
100g/週 (14g/日) |
注：上記の飲酒量(純アルコール量)の数値のうち、「研究結果」の欄の数値については、参考文献に基づく研究結果によるもので、これ以上の飲酒をすると発症等のリスクが上がると考えられるもの。「参考」の欄にある数値については、研究結果の数値をもとに、仮に7で除した場合の参考値(概数)。「0g＜」は少しでも飲酒をするとリスクが上がると考えられるもの。「関連なし」は飲酒量(純アルコール量)とは関連が無いと考えられるもの。「データなし」は飲酒量(純アルコール量)と関連するデータがないもの。「※」は現在研究中のもの。なお、これらの飲酒量(純アルコール量)については、すべて日本人に対する研究に基づくものとなります。
参考文献
脳卒中
A) Ikehara S, Iso H, Yamagishi K, Kokubo Y, Saito I, Yatsuya H, Inoue M, Tsugane S; JPHC Study Group: Alcohol consumption and risk of stroke and coronary heart disease among Japanese women: the Japan Public Health Center[1]based prospective study. Prev Med. 2013; 57(5): 505-510.
B) Iso H, Baba S, Mannami T, Sasaki S, Okada K, Konishi M, Tsugane S; JPHC Study Group: Alcohol consumption and risk of stroke among middle-aged men: the JPHC Study Cohort I. Stroke. 2004; 35(5): 1124-1129.
C) Ikehara S, Iso H, Yamagishi K, Yamamoto S, Inoue M, Tsugane S; JPHC Study Group: Alcohol consumption, social support, and risk of stroke and coronary heart disease among Japanese men: the JPHC Study. Alcohol Clin Exp Res. 2009; 33(6): 1025-1032.
出血性脳卒中
A) Ikehara S, Iso H, Yamagishi K, Kokubo Y, Saito I, Yatsuya H, Inoue M, Tsugane S; JPHC Study Group: Alcohol consumption and risk of stroke and coronary heart disease among Japanese women: the Japan Public Health Center[1]based prospective study. Prev Med. 2013 ;57(5): 505-510.
B) Iso H, Baba S, Mannami T, Sasaki S, Okada K, Konishi M, Tsugane S; JPHC Study Group: Alcohol consumption and risk of stroke among middle-aged men: the JPHC Study Cohort I. Stroke. 2004; 35(5): 1124-1129.
C) Ikehara S, Iso H, Yamagishi K, Yamamoto S, Inoue M, Tsugane S; JPHC Study Group: Alcohol consumption, social support, and risk of stroke and coronary heart disease among Japanese men: the JPHC Study. Alcohol Clin Exp Res. 2009; 33(6): 1025-1032.
D) Sankai T, Iso H, Shimamoto T, Kitamura A, Naito Y, Sato S, Okamura T, Imano H, Iida M, Komachi Y: Prospective study on alcohol intake and risk of subarachnoid hemorrhage among Japanese men and women. Alcohol Clin Exp Res. 2000; 24(3): 386-389.
脳梗塞
A) Ikehara S, Iso H, Yamagishi K, Kokubo Y, Saito I, Yatsuya H, Inoue M, Tsugane S; JPHC Study Group: Alcohol consumption and risk of stroke and coronary heart disease among Japanese women: the Japan Public Health Center[1]based prospective study. Prev Med. 2013; 57(5): 505-510.
B) Iso H, Baba S, Mannami T, Sasaki S, Okada K, Konishi M, Tsugane S; JPHC Study Group: Alcohol consumption and risk of stroke among middle-aged men: the JPHC Study Cohort I. Stroke. 2004; 35(5): 1124-1129.
C) Ikehara S, Iso H, Yamagishi K, Yamamoto S, Inoue M, Tsugane S; JPHC Study Group: Alcohol consumption, social support, and risk of stroke and coronary heart disease among Japanese men: the JPHC Study. Alcohol Clin Exp Res. 2009; 33(6): 1025-1032. 13
虚血性心疾患
A) Ikehara S, Iso H, Yamagishi K, Kokubo Y, Saito I, Yatsuya H, Inoue M, Tsugane S; JPHC Study Group: Alcohol consumption and risk of stroke and coronary heart disease among Japanese women: the Japan Public Health Center[1]based prospective study. Prev Med. 2013; 57(5): 505-510.
B) Ikehara S, Iso H, Yamagishi K, Yamamoto S, Inoue M, Tsugane S; JPHC Study Group: Alcohol consumption, social support, and risk of stroke and coronary heart disease among Japanese men: the JPHC Study. Alcohol Clin Exp Res. 2009; 33(6): 1025-1032.
C) Makita S, Onoda T, Ohsawa M, Tanaka F, Segawa T, Takahashi T, Satoh K, Itai K, Tanno K, Sakata K, Omama S, Yoshida Y, Ishibashi Y, Koyama T, Kuribayashi T, Ogasawara K, Ogawa A, Okayama A, Nakamura M: Influence of mild-to[1]moderate alcohol consumption on cardiovascular diseases in men from the general population. Atherosclerosis. 2012; 224(1): 222-227.
D) Nakamura Y, Kita Y, Iso H, Ueshima H, Okada K, Konishi M, Inoue M, Tsugane S; JPHC Study Group: Alcohol consumption, alcohol-induced flushing and incidence of acute myocardial infarction among middle-aged men in Japan— Japan Public Health Center-based prospective study. Atherosclerosis. 2007; 194(2): 512-516.
胃がん
A) Li Y, Eshak ES, Shirai K, Liu K, Dong JY, Iso H, Tamakoshi A; JACC Study Group: Alcohol Consumption and Risk of Gastric Cancer: The Japan Collaborative Cohort Study. J Epidemiol. 2021; 31(1): 30-36.
B) Tamura T, Wada K, Tsuji M, Konishi K, Kawachi T, Hori A, Tanabashi S, Matsushita S, Tokimitsu N, Nagata C: Association of alcohol consumption with the risk of stomach cancer in a Japanese population: a prospective cohort study. Eur J Cancer Prev. 2018; 27(1): 27-32.
C) Tamura T, Wakai K, Lin Y, Tamakoshi A, Utada M, Ozasa K, Sugawara Y, Tsuji I, Ono A, Sawada N, Tsugane S, Ito H, Nagata C, Kitamura T, Naito M, Tanaka K, Shimazu T, Mizoue T, Matsuo K, Inoue M; Research Group for the Development and Evaluation of Cancer Prevention Strategies in Japan: Alcohol intake and stomach cancer risk in Japan: A pooled analysis of six cohort studies. Cancer Sci. 2022; 113(1): 261-276.
D) Nakaya N, Tsubono Y, Kuriyama S, Hozawa A, Shimazu T, Kurashima K, Fukudo S, Shibuya D, Tsuji I: Alcohol consumption and the risk of cancer in Japanese men: the Miyagi cohort study. Eur J Cancer Prev. 2005; 14(2): 169-174.
肺がん
A) Shimazu T, Inoue M, Sasazuki S, Iwasaki M, Kurahashi N, Yamaji T, Tsugane S; Japan Public Health Center-based Prospective Study Group: Alcohol and risk of lung cancer among Japanese men: data from a large-scale population-based cohort study, the JPHC study. Cancer Causes Control. 2008; 19(10): 1095- 1102. 14
B) Nakaya N, Tsubono Y, Kuriyama S, Hozawa A, Shimazu T, Kurashima K, Fukudo S, Shibuya D, Tsuji I: Alcohol consumption and the risk of cancer in Japanese men: the Miyagi cohort study. Eur J Cancer Prev. 2005; 14(2): 169-174.
大腸がん
A) Ma E, Sasazuki S, Iwasaki M, Sawada N, Inoue M, Tsugane S; Japan Public Health Center-based Prospective Study Group: 10-Year risk of colorectal cancer: development and validation of a prediction model in middle-aged Japanese men. Cancer Epidemiol. 2010; 34(5): 534-541.
B) Akhter M, Kuriyama S, Nakaya N, Shimazu T, Ohmori K, Nishino Y, Tsubono Y, Fukao A, Tsuji I: Alcohol consumption is associated with an increased risk of distal colon and rectal cancer in Japanese men: the Miyagi Cohort Study. Eur J Cancer. 2007;43(2): 383-390.
C) Otani T, Iwasaki M, Yamamoto S, Sobue T, Hanaoka T, Inoue M, Tsugane S; Japan Public Health Center-based Prospective Study Group: Alcohol consumption, smoking, and subsequent risk of colorectal cancer in middle[1]aged and elderly Japanese men and women: Japan Public Health Center-based prospective study. Cancer Epidemiol Biomarkers Prev. 2003; 12(12): 1492- 1500.
D) Wakai K, Kojima M, Tamakoshi K, Watanabe Y, Hayakawa N, Suzuki K, Hashimoto S, Kawado M, Tokudome S, Suzuki S, Ozasa K, Toyoshima H, Ito Y, Tamakoshi A; JACC Study Group: Alcohol consumption and colorectal cancer risk: findings from the JACC Study. J Epidemiol. 2005; 15 Suppl 2(Suppl II): S173-S179.
E) Shimizu N, Nagata C, Shimizu H, Kametani M, Takeyama N, Ohnuma T, Matsushita S: Height, weight, and alcohol consumption in relation to the risk of colorectal cancer in Japan: a prospective study. Br J Cancer. 2003; 88(7): 1038-1043.
F) Nakaya N, Tsubono Y, Kuriyama S, Hozawa A, Shimazu T, Kurashima K, Fukudo S, Shibuya D, Tsuji I: Alcohol consumption and the risk of cancer in Japanese men: the Miyagi cohort study. Eur J Cancer Prev. 2005; 14(2): 169-174.
G) Mizoue T, Inoue M, Wakai K, Nagata C, Shimazu T, Tsuji I, Otani T, Tanaka K,Matsuo K, Tamakoshi A, Sasazuki S, Tsugane S; Research Group for Development and Evaluation of Cancer Prevention Strategies in Japan: Alcohol drinking and colorectal cancer in Japanese: a pooled analysis of results from five cohort studies. Am J Epidemiol. 2008; 167(12): 1397-1406.
食道がん
A) Ishikawa A, Kuriyama S, Tsubono Y, Fukao A, Takahashi H, Tachiya H, Tsuji I: Smoking, alcohol drinking, green tea consumption and the risk of esophageal cancer in Japanese men. J Epidemiol. 2006; 16(5): 185-192.
B) Ishiguro S, Sasazuki S, Inoue M, Kurahashi N, Iwasaki M, Tsugane S; JPHC Study Group: Effect of alcohol consumption, cigarette smoking and flushing response on esophageal cancer risk: a population-based cohort study (JPHC study). Cancer Lett. 2009; 275(2): 240-246. 15
C) Nakaya N, Tsubono Y, Kuriyama S, Hozawa A, Shimazu T, Kurashima K, Fukudo S, Shibuya D, Tsuji I: Alcohol consumption and the risk of cancer in Japanese men: the Miyagi cohort study. Eur J Cancer Prev. 2005; 14(2): 169-174.
乳がん
A) Kawai M, Minami Y, Kakizaki M, Kakugawa Y, Nishino Y, Fukao A, Tsuji I, Ohuchi N: Alcohol consumption and breast cancer risk in Japanese women: the Miyagi Cohort study. Breast Cancer Res Treat. 2011; 128(3): 817-825.
B) Suzuki R, Iwasaki M, Inoue M, Sasazuki S, Sawada N, Yamaji T, Shimazu T, Tsugane S; Japan Public Health Center Based Prospective Study Group: Alcohol consumption-associated breast cancer incidence and potential effect modifiers: the Japan Public Health Center-based Prospective Study. Int J Cancer. 2010; 127(3): 685-695.
C) Lin Y, Kikuchi S, Tamakoshi K, Wakai K, Kondo T, Niwa Y, Yatsuya H, Nishio K, Suzuki S, Tokudome S, Yamamoto A, Toyoshima H, Tamakoshi A: Prospective study of alcohol consumption and breast cancer risk in Japanese women. Int J Cancer. 2005; 116(5): 779-783.
D) Iwase M, Matsuo K, Koyanagi YNY, Ito H, Tamakoshi A, Wang C, Utada M, Ozasa K, Sugawara Y, Tsuji I, Sawada N, Tanaka S, Nagata C, Kitamura Y, Shimazu T, Mizoue T, Naito M, Tanaka K, Inoue M: Alcohol consumption and breast cancer risk in Japan: A pooled analysis of eight population-based cohort studies. Int J Cancer. 2021 Jun 1; 148(11): 2736-2747.
E) Sinnadurai S, Okabayashi S, Kawamura T, Mori M, Bhoo-Pathy N, Taib NA, Ukawa S, Tamakoshi A, The JACC Study Group: Intake of Common Alcoholic and Non[1]Alcoholic Beverages and Breast Cancer Risk among Japanese Women: Findings from the Japan Collaborative Cohort Study. Asian Pac J Cancer Prev. 2020; 21(6): 1701-1707.
F) Nitta J, Nojima M, Ohnishi H, Mori M, Wakai K, Suzuki S, Fujino Y,Lin Y, Tamakoshi K, Tamakoshi A: Weight Gain and Alcohol Drinking Associations with Breast Cancer Risk in Japanese Postmenopausal Women -Results from the Japan Collaborative Cohort (JACC) Study. Asian Pac J Cancer Prev. 2016; 17(3): 1437-1443.
肝がん
A) Shimazu T, Sasazuki S, Wakai K, Tamakoshi A, Tsuji I, Sugawara Y, Matsuo K, Nagata C, Mizoue T, Tanaka K, Inoue M, Tsugane S; Research Group for the Development and Evaluation of Cancer Prevention Strategies in Japan: Alcohol drinking and primary liver cancer: a pooled analysis of four Japanese cohort studies. Int J Cancer. 2012; 130(11): 2645-2653
B) Nakaya N, Tsubono Y, Kuriyama S, Hozawa A, Shimazu T, Kurashima K, Fukudo S, Shibuya D, Tsuji I: Alcohol consumption and the risk of cancer in Japanese men: the Miyagi cohort study. Eur J Cancer Prev. 2005; 14(2): 169-174.
前立腺がん
A) Sawada N, Inoue M, Iwasaki M, Sasazuki S, Yamaji T, Shimazu T, Tsugane S. Alcohol and smoking and subsequent risk of prostate cancer in Japanese men: 16 the Japan Public Health Center-based prospective study. Int J Cancer. 2014; 134(4): 971-978.
高血圧
A) Nakanishi N, Nakamura K, Ichikawa S, Suzuki K, Kawashimo H, Tatara K. Risk factors for the development of hypertension: a 6-year longitudinal study of middle-aged Japanese men. J Hypertens. 1998; 16(6): 753-759.
B) Nakanishi N, Kawashimo H, Nakamura K, Suzuki K, Yoshida H, Uzura S, Tatara K: Association of alcohol consumption with increase in aortic stiffness: a 9-year longitudinal study in middle-aged Japanese men. Ind Health. 2001; 39(1): 24-28.
C) Nakanishi N, Makino K, Nishina K, Suzuki K, Tatara K: Relationship of light to moderate alcohol consumption and risk of hypertension in Japanese male office workers. Alcohol Clin Exp Res. 2002; 26(7): 988-994.
D) Okubo Y, Sairenchi T, Irie F, Yamagishi K, Iso H, Watanabe H, Muto T, Tanaka K, Ota H: Association of alcohol consumption with incident hypertension among middle-aged and older Japanese population: the Ibarakai Prefectural Health Study (IPHS). Hypertension. 2014 Jan; 63(1): 41-47
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